Analysis of the 2025 IDF Global T2DM Guidelines: Metformin Explicitly Designated as First-Line Foundation Therapy

In the 2025 updated guidelines for type 2 diabetes mellitus (T2DM) management released by the International Diabetes Federation (IDF), the classic glucose-lowering drug metformin remains explicitly designated as the first-line foundational therapeutic agent. This recommendation is grounded in robust evidence accumulated over more than a century since its introduction, efficacy and safety repeatedly validated in […]

I Am Metformin — Do You Know Me?

In the 1950s, my big family — the biguanide class of drugs — was born.My eldest brother is buformin, my second brother is phenformin, and I am the youngest: metformin (generic name).I am one of the most commonly used oral antidiabetic medications.Yet few drugs have traveled such a long and winding road as I have.For […]