I. Pancreatic β-Cells Under Lipotoxic AttackHyperlipidemia acts as a hidden silent killer, especially the surge in free fatty acids and triglycerides, which inflicts lipotoxicity on pancreatic β-cells.Excess lipid deposition in β-cells opens a Pandora’s box, triggering endoplasmic reticulum stress and mitochondrial dysfunction, severely inhibiting insulin synthesis and secretion.Under long-term lipotoxic assault, β-cells may undergo apoptosis, […]